Corticalis is focused on the continued development of its totally owned,

new technologies, NuBone and NuBone Clean.


Conditions such as trauma, tumors, cancer, periodontitis and osteoporosis may lead to bone loss, reduced bone growth and bone volume. For these and other reasons, it is of great importance to find methods to improve bone growth and to regain bone anatomy. Scaffolds may be used as a framework for the cells participating in the bone regeneration process, but also as a framework as a substitute for the lost bone structure.

Natural bone tissue formation from osteogenic cells with the aid of a three-dimensional scaffold offers an alternative to autografts and allografts to repair and regenerate lost bone.

A well-constructed scaffold provides a suitable surface for cells to attach and adhere with a porous and well interconnected network guiding the development of new bone, supporting migration, proliferation and differentiation of bone-forming cells and vascularization of the ingrowth tissue.

The goal of the R & D was to create the next generation bone graft substitute with large porosity, high mechanical strength, as well as good biocompatibility and high bone ingrowth. Further, it was desirable if the bone graft substitute could be drilled into and implants inserted through.

The manufacturing process should not be complicated and expensive and the transfer of the technology from the research laboratory to a manufacturing facility should be straightforward.

Through its research, Corticalis has been able to
develop a metal oxide Scaffold (TiO2) that shows the
following characteristics:
• Highly porous (>85%)
• High mechanical strength (>3.4 Mpa)
• Substantial vital bone ingrowth in vivo
• Extremely high interconnectivity
• Biocompatible
Non-toxic, non-allergic, or foreign body response.

NuBone has obtained CE Certificate in compliance with Annex II of the directive 93/42/EEC.


NuBone Clean

Peri-implantitis is a site specific infectious disease that causes an inflammatory process in soft tissues, and bone loss around an osseointegrated implant in function. Implant failure has classically been attributed to, among other things, bacterial infections. Bacterial infections are in many cases a result of the difficulties many implant patients have with keeping their dental implants clean.

Despite objections from the implant industry, it has been shown that a large portion patients with dental implant suffers from peri-implantatis. In order to address this problem, Corticalis has developed a paste for peri-implantitis treatment, NuGel™.

NuGel is a gel that debrides implanted implants on a nano-level. It effectively removes substantially all of the bacteria causing peri-implantis and thus greatly reduce the risk of peri-implantis due to bacteria. In addition to this, NuGel has an anti-inflammatory effect.